Human topoisomerase II alpha (TopoIIα) is an enzyme involved in maintaining genomic integrity during the process of DNA replication and mitotic division. It is a vital therapeutic target for designing novel anticancer agents in targeted cancer therapy.  In the present work, a series of sulfones was selected to evaluate their inhibitory activity against TopoIIα using … Continue reading Molecular dynamics simulations of sulfone derivatives in complex with DNA topoisomerase IIa ATPase domain